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The all natural Bio-Filler or EZGel is the latest and the most exciting aesthetic procedure that we have introduced and a 100% natural alternative to synthetic fillers.

All natural Bio-Filler is produced from components in the patient’s own blood and are injected in a similar fashion as other synthetic fillers to add volume, contour, lift and rejuvenate the skin in areas like face, neck, hands, ect. Bio-Filler can be injected in the cheeks, jawline, chin, areas around the eyes & mouth, nasolabial folds, lips, neck, back of the hands, stretch marks and more. The autologous nature of Bio-Filler minimizes any risk of side effects, rejection, and/or allergies and the ability to harvest large doses of Bio-Filler from a simple blood draw makes Bio-Filler an extremely attractive aesthetic procedure with immediate and progressive results. Bio-Filler has the same color and consistency as autologous fat, but becomes softer when injected allowing the results to be more precise and refined.

Bio-Filler can be injected in the cheeks, jawline, chin, areas around the mouth, temples, nasolabial folds, lips, neck, and back of the hands in the same fashion as dermal fillers.

Unlike synthetic fillers, Bio-Filler contains a high concentration of the patient’s own growth factors that repair and proliferate damaged cells and stimulate collagen production meaning your skin will be naturally reproducing itself for months after the injections. The results of Bio-Filler are immediate and stable for several months until it is metabolized by the body. The expected rejuvenating benefits of Bio-Filler are generally visible at 6-8 weeks after the treatment and continue to gradually improve over 6 months or longer. Longevity of the result is dependent on many factors including but not limited to age, health, lifestyle, skin conditions, areas of injection, the amount injected, and metabolism. Without periodic touchup injections, the improvements will gradually wear off.


After the age of 20, the collagen production rate in our skin declines by about 1% every year. Gulp!

One of the great things about all natural Bio-Filler treatments is there is very little downtime and the procedure does not take long to complete. Prior to your treatment, you will discuss your concerns and goals with one of our specialists to determine if Bio-Filler is the right procedure for you. Once a treatment plan is created, your specialist will determine how much product is needed and this will dictate how much blood sample is required. Coming to your visit well hydrated will help ensure an adequate amount of blood sample is collected. Bio-Filler is created by mixing the platelet-rich fibrin (PRF) with albumin-rich plasma that has been heated and cooled. This combination allows for a natural and smooth bio-stimulating filler to be formed – all from your blood sample without any additives. This gel-like filler mixture is then injected directly into the problem areas, adding an instant volume boost that will continue to provide growth factor release and stimulation over time.

Bio-Filler ( EzGEL ) =
PRF + Plasma Albumin

The nature of the Bio-Filler procedure may require a patient to return for a series of treatments, spaced 6 – 8 weeks apart in order to achieve the desired results. Results typically last a few weeks and the volume will essentially dissipate. Long-term effects, such as skin tightening, collagen production and enhanced skin quality, may take up to 3 – 4 months to be noticed and can last 6 months or longer. Significant results can last as long as two years.

The number of treatments needed is dependent on the area that is being treated as well as the condition that is being addressed. We will discuss this with you at your complimentary consultation. Good general health is the key to excellent and predictable outcomes.

Hand Rejuvenation with 100% All-Natural Bio-Filler.

Do you want to find out if the all natural Bio-Filler is the right aesthetic treatment for you? Contact Avissa Skin clinic today for more information on the best Natural Bio-Filler Procedure in Ann Arbor  Michigan, for information on other cosmetic procedures, or to schedule a consultation. We look forward to hearing from you!